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Clinical and Translational Medicine, 2022
Sep;12(9):e1050.doi: 10.1002/ctm2.1050.
CRBN is downregulated in lung cancer and negatively regulates
TLR2, 4 and 7 stimulation in lung cancer cells
Mi-Jeong Kim, Ji Su Lee, Ji Young Kim, Bongkum Choi, Juhee Son, Yoon Min, Soo-Kyung Jeong, Duk-Hwan Kim, Joo Sang Lee, Eunyoung Chun, Ki-Young Lee
Abstract
Dear
Editor,
Cereblon
(CRBN) has been identified as a primary target of immunomodulatory drugs in
multiple myeloma.1 Herein, for the first time, we demonstrate that CRBN
expression is functionally involved in lung cancer progression through the
regulation of autophagy by toll-like receptor (TLR)2, TLR4 and TLR7. TLR
signalling is associated with the induction of autophagy and plays a pivotal
role in the progression and pathogenesis of lung cancer.2 Our study suggests
that CRBN can be a potent prognostic marker for lung cancer and provides
important implications in clinical and translational lung cancer biology
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